Rabbit Secondary Antibodies
ABclonal Technology eIF4EBP1 Rabbit mAb
This gene encodes one member of a family of translation repressor proteins The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E) which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5 end of mRNAs Interaction of this protein with eIF4E inhibits complex assembly and represses translation This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling resulting in its dissociation from eIF4E and activation of mRNA translation
ABclonal Technology TPH-1 Rabbit mAb
This gene encodes a member of the aromatic amino acid hydroxylase family The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin an important hormone and neurotransmitter Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders including schizophrenia somatic anxiety anger-related traits bipolar disorder suicidal behavior addictions and others
Jackson Immuno Research Labs Alexa Fluor 488-AffiniPure F(ab')2 Fragment Rabbit Anti-Mouse IgG (H+L)
Alexa Fluor 488-AffiniPure F(ab')2 Fragment Rabbit Anti-Mouse IgG (H+L)
Cayman Chemical PD1CD279NTerm RabbIt Mo 100uL
A quaternary ammonium-containing cationic surfactant with diverse biological activities an inhibitor of F. tularensis AcpB (Ki 0.59 UM) and C. albicans V-ATPase (EC50 69 UM) inhibits osteoclastogenesis RANKL-induced osteoclastogenesis in BMDMs inhibits bone resorption by mature osteoclasts at 100 and 200 nM prevents LPS-induced bone loss in a calvarial osteolytic mouse model at 5 mg/kg per day induces mortality in C. oncophora O. ostertagi H. contortus and T. circumcincta (EC50s 4.5 10.8 5.1 and 6.7 UM respectively) but is cytotoxic to HEK293 and RAW 264.7 cells (CC50s 9.2 and 5.7 UM respectively)
Cayman Chemical ZAP70NTerm RabbIt Moncl 100uL
A synthetic intermediate has been used in the synthesis of ANANAS and chemotherapeutic conjugates
Cayman Chemical cFosNTerm RabbIt Monclo 100uL
A synthetic intermediate has been used in the synthesis of ANANAS and chemotherapeutic conjugates
ABclonal Technology B-Actin Rabbit mAb
This gene encodes one of six different actin proteins Actins are highly conserved proteins that are involved in cell motility structure integrity and intercellular signaling The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed Mutations in this gene cause Baraitser-Winter syndrome 1 which is characterized by intellectual disability with a distinctive facial appearance in human patients Numerous pseudogenes of this gene have been identified throughout the human genome
ABclonal Technology Rab12 Rabbit mAb MJFF-A-3F6
Rab12 a member of the RAS oncogene family is crucial for intracellular membrane trafficking This small GTPase transports vesicles from recycling endosomes to lysosomes and is essential for autophagy and transferrin receptor degradation Rab12 cycles between inactive GDP-bound and active GTP-bound forms recruiting effectors for vesicle movement and fusion It is phosphorylated by LRRK2 (Leucine-Rich Repeat Kinase 2) and also regulates LRRK2 activity Rab12 activates LRRK2 which increases phosphorylation of Rab10 another trafficking protein especially in lysosomal damage Dysregulation of this pathway due to LRRK2 mutations is linked to neurodegeneration in Parkinson s disease
ABclonal Technology GMNN Rabbit mAb
This gene encodes a protein that plays a critical role in cell cycle regulation The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1 preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition Increased expression of this gene may play a role in several malignancies including colon rectal and breast cancer Alternatively spliced transcript variants have been observed for this gene and two pseudogenes of this gene are located on the short arm of chromosome 16
ABclonal Technology RBBP5 Rabbit mAb
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins The encoded protein binds directly to retinoblastoma protein which regulates cell proliferation It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene
ABclonal Technology 488 Rabbit anti-Human CD2
The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition A locus control region (LCR) has been found in the 3 flanking sequence of this gene
ABclonal Technology 594 Rabbit anti-Human IL8
The protein encoded by this gene is interleukin-8 (IL-8) a major mediator of inflammation and a member of the CXC chemokine family IL-8 is secreted by macrophages neutrophils eosinophils T lymphocytes epithelial cells and fibroblasts guiding neutrophils to infection sites It is rapidly induced by bacterial and viral products and contributes to the proinflammatory cascade playing a role in systemic inflammatory response syndrome (SIRS) IL-8 is involved in conditions like bronchiolitis cystic fibrosis coronary artery disease and endothelial dysfunction It also promotes tumor migration invasion angiogenesis and metastasis IL-8 binds to its receptor (CXCR2) increasing blood vessel permeability Elevated IL-8 levels correlate with worsened disease outcomes including sepsis This gene is part of a CXC chemokine cluster on chromosome 4q
Immunology Consultants anti-Human IgG h+l Antibody (Rabbit) - Affinity Purified
RGHL‑80A is an affinity‑purified rabbit antibody targeting human IgG heavy and light chains, suitable for use as a secondary antibody in immunoassays. This reagent provides strong specificity, low background, and consistent performance in ELISA, Western blotting, and immunodetection workflows involving human primary antibodies. Produced by Immunology Consultants and supplied in a 1 mg format, RGHL‑80A is a reliable reagent for human IgG detection.
ABclonal Technology PE Rabbit anti-Human CD28 mAb
The protein encoded by this gene is essential for T-cell proliferation and survival cytokine production and T-helper type-2 development Several alternatively spliced transcript variants encoding different isoforms have been found for this gene