Rabbit Secondary Antibodies
ABclonal Technology AGER Rabbit mAb
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors It is a multiligand receptor and besides AGE interacts with other molecules implicated in homeostasis development and inflammation and certain diseases such as diabetes and Alzheimer s disease Many alternatively spliced transcript variants encoding different isoforms as well as non-protein-coding variants have been described for this gene (PMID 18089847)
ABclonal Technology 647 Rabbit anti- CD270/HVEM
Predicted to enable cytokine binding activity and ubiquitin protein ligase binding activity Acts upstream of or within several processes including defense response to bacterium negative regulation of alpha-beta T cell proliferation and positive regulation of macromolecule metabolic process Located in external side of plasma membrane Is expressed in liver lobe Orthologous to human TNFRSF14 (TNF receptor superfamily member 14)
ABclonal Technology ABflo 647 Rabbit anti- CD79b
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component surface immunoglobulin (Ig) Surface Ig non-covalently associates with two other proteins Ig-alpha and Ig-beta which are necessary for expression and function of the B-cell antigen receptor This gene encodes the Ig-beta protein of the B-cell antigen component Alternatively spliced transcript variants encoding different isoforms have been described
ABclonal Technology DDR1/MCK10/CD167a Rabbit mAb
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment These kinases are involved in the regulation of cell growth differentiation and metabolism The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain and that are activated by various types of collagen Expression of this protein is restricted to epithelial cells particularly in the kidney lung gastrointestinal tract and brain In addition it has been shown to be significantly overexpressed in several human tumors Alternatively spliced transcript variants encoding different isoforms have been described for this gene
ABclonal Technology SMARCA2 / BRM Rabbit mAb
The protein encoded by this gene is a member of the SWI SNF family of proteins and is highly similar to the brahma protein of Drosophila Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF SWI which is required for transcriptional activation of genes normally repressed by chromatin Alternatively spliced transcript variants encoding different isoforms have been found for this gene which contains a trinucleotide repeat (CAG) length polymorphism
ABclonal Technology ZNF20 Rabbit mAb
Predicted to enable DNA-binding transcription repressor activity RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity Predicted to be involved in negative regulation of transcription by RNA polymerase II Predicted to be located in nucleus
Cayman Chemical B7H3CD276CTerm RabbIt M 100uL
A quaternary ammonium-containing cationic surfactant with diverse biological activities an inhibitor of F. tularensis AcpB (Ki 0.59 UM) and C. albicans V-ATPase (EC50 69 UM) inhibits osteoclastogenesis RANKL-induced osteoclastogenesis in BMDMs inhibits bone resorption by mature osteoclasts at 100 and 200 nM prevents LPS-induced bone loss in a calvarial osteolytic mouse model at 5 mg/kg per day induces mortality in C. oncophora O. ostertagi H. contortus and T. circumcincta (EC50s 4.5 10.8 5.1 and 6.7 UM respectively) but is cytotoxic to HEK293 and RAW 264.7 cells (CC50s 9.2 and 5.7 UM respectively)
ABclonal Technology SMPD3/NSMase2 Rabbit mAb
Predicted to enable phosphatidic acid binding activity phosphatidylserine binding activity and sphingomyelin phosphodiesterase activity Predicted to be involved in positive regulation of exosomal secretion and sphingomyelin metabolic process Predicted to act upstream of or within several processes including animal organ development enzyme linked receptor protein signaling pathway and sphingolipid metabolic process Predicted to be located in Golgi apparatus and plasma membrane Predicted to be active in cytoplasm Biomarker of pulmonary emphysema
Cayman Chemical ProsteInCTerm RabbIt Mon 100uL
A flavonoid glycoside with diverse biological activities inhibits CAVII (Ki 4 6 nM) scavenges DPPH and superoxide radicals (IC50s 12 8 and 42 UM respectively) cytotoxic to Jurkat HepG2 and COLO 205 cells (IC50s 11 6 14 3 and 55 4 UM respectively) reduces TPA-induced ear edema (ID50 0 357 mg/ear) decreases triglyceride accumulation in the liver and skeletal muscle in high-fat diet-fed KKAy diabetic mice at 100 mg/kg
Cayman Chemical CD4NTerm RabbIt Monclona 100uL
An inhibitor of B-RAF and C-RAF (IC50s 41 7 and 2 nM for wild-type B-RAF B-RAFV600E and wild-type C-RAF respectively) cytotoxic to B-RAFV600E-expressing A375 and SK-MEL-28 melanoma cells (IC50s 57 and 69 nM respectively) as well as COLO 205 and HCT116 colon and B-CPAP and CAL-62 thyroid cancer cells (IC50s 116 65 43 and 479 nM respectively) reduces tumor growth in A375 SK-MEL-28 SK-MEL-2 and SK-MEL-30 mouse xenograft models